Carlos María Morales-Garzón¹ ², Kamal Hammu-Mohamed¹ ², José Ignacio Moral-Vázquez¹ ².
- Faculty of Medicine, University of Granada (UGR).
- Lung Development Project, University of Granada (UGR).
Ana García-Canteli³, Irene Ruiz-González³, Belén Romero-Pastor³, Carla Arco-López³, Pedro Hurtado-Ruiz³, Julia Santos-Sánchez.
- Faculty of Translation and Interpreting, University of Granada (UGR).
The growing epidemiological relevance of breast cancer has led to a large increase in studies investigating how to prevent it. The lower incidence of the disease in Asia was associated with the high soy intake of that region. Accordingly, soy contains isoflavones, which have structural similarities to estrogens and could act as agonists or antagonists. In this review, we gathered evidence on the effect of soy as a protective agent, concerning both the regular soyfood intake during life and the use of soy supplements in postmenopausal women. Current scientific knowledge appears to indicate that soy intake is a protective agent against breast cancer in premenopausal women. However, not all studies point in the same direction. Finally, the use of supplements in risk and postmenopausal patients may be more of a risk factor than a protective one.
Keywords: breast cancer, soy, isoflavones.